Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

Investigation of genetic factors associated with polycystic ovary syndrome

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders and causes 75% of infertility due to ovulation disorders in reproductive age. Women with PCOS have oligomenorrhea and hyperandrogenism that affect their quality of life and fertility at the same time. This syndrome has been one of the most controversial endocrine issues for many years. Research today su...

Glycogen Synthase Kinase-3

1Department of Pathology and Centre for Neuroscience, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia 2Neurosignalling Group, Garvan Institute for Medical Research, 384 Victoria St. Darlinghurst, Sydney, NSW 2010, Australia 3Membrane Biology Group, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK 4 ...

GENETIC AND NON-GENETIC THEORIES ON THE ETIOLOGY OF POLYCYSTIC OVARY SYNDROME: A REVIEW

Glycogen synthase kinase-3β may contribute to neuroprotective effects of Sargassum oligocystum against amyloid-beta in neuronal SH-SY5Y cells

Glycogen synthase kinase (GSK)-3β mediates amyloid-beta (Aβ) and oxidative stress-induced neurotoxicity in neurodegenerative disorders. Natural products with antioxidant activity, such as Sargassum (S.) oligocystum may modulate GSK-3β enzyme and protect against Aβ-induced neurotoxicity. Therefore, we aimed to assess the neuroprotective effects of a methanolic extract of S. oligocystum against A...

The genetic basis of polycystic ovary syndrome.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. The disorder is characterized by clinical features of hyperandrogenism, menstrual irregularities and often central obesity and hyperinsulinaemia. PCOS may increase the risk for infertility, type 2 diabetes mellitus, dyslipidaemia, cardiovascular disease and endometrial cancer, emphasizing the need for ...